Introduction:

Human in vivo wound healing model. Full-thickness excisional wounds (4mm in diameter) are created on the skin of healthy volunteers and wound-edge tissues are collected with 6mm biopsy punches 1, 7, and 30 days later from the same donor. The time points are chosen to capture the three sequential phases of wound repair, i.e., inflammation (~3 days), proliferation (~4-21 days), and remodelling (~21days-one year).