-------------------- 2020 --------------------

27. Dongqing Li, Shangli Cheng, Yu Pei, Pehr Sommar, Jaanika Kärner, Eva K. Herter, Maria A. Toma,  Letian Zhang, Kim Pham, Yuen Ting Cheung, Xingqi Chen, Liv Eidsmo, Qiaolin Deng, Ning Xu Landén. bioRxiv  2021.04.20.440591;  doi: https://doi.org/10.1101/2021.04.20.440591

26. Piipponen M, Li D, Xu Landén N.# The immune functions of keratinocytes in skin wound healing. Int. J. Mol. Sci. 2020, 21, 8790. (Review)

25. Narayanan S, Angelstig S E, Xu C, Grünler J, Zhao A, Zhu W, Xu Landén N, Ståhle M, Zhang J, Ivan M, Maltesen R G, Botusan I R, Ekberg N R, Zheng X, Catrina S-B. HypoxamiR-210 accelerates wound healing in diabetic mice by improving cellular metabolism. Commun Biol 3, 768 (2020).

24. Li D, Peng H, Qu L, Sommar P, Wang A, Chu T, Li X, Bi X, Liu Q, Sérézal IG, Rollman O, Lohcharoenkal W, Zheng X, Angelstig SE, Grünler J, Pivarcsi A, Sonkoly E, Catrina S-B, Xiao C, Ståhle M, Mi Q-S, Zhou L#, Xu Landén N. miR-19a/b and miR-20a promote wound healing by regulating the inflammatory response of keratinocytes. Journal of Investigative Dermatology, Accepted on June 29th, 2020.

23. Li X, Landén NX. Evaluation of MicroRNA Therapeutic Potential Using the Mouse In Vivo and Human Ex Vivo Wound Models. Methods in Molecular Biology, 2020;2193:67-75. PMID: 32808259.

22. Wu J, Landén NX. Investigation of Skin Wound Healing Using a Mouse Model. Methods Mol Biol. 2020;2154:239‐247. doi:10.1007/978-1-0716-0648-3_20.


-------------------- 2019 --------------------

21. Aoxue Wang*, Maria A*. Toma, Jingxin Ma, Dongqing Li, Manika Vij, Tongbin Chu, Jing Wang, Xi Li, Ning Xu Landén. Circular RNA hsa_circ_0084443 is upregulated in diabetic foot ulcer and modulates keratinocyte migration and proliferation. Adv Wound Care (New Rochelle). 2019 (Accepted for publucation)

20. Wu J*, Li X*, Li D, Ren X, Li Y, Herter EK, Qian M, Toma MA, Wintler AM, Sérézal IG, Rollman O, Ståhle M, Wikstrom JD, Ye X, Landén NX. MicroRNA-34 family enhances wound inflammation by targeting LGR4. J Invest Dermatol. 2019 Jul 31. pii: S0022-202X(19)32680-6. doi: 10.1016/j.jid.2019.07.694. [Epub ahead of print] PubMed PMID: 31376385.

19. Srivastava A, Meisgen F, Pasquali L, Munkhammar S, Xia P, Ståhle M, Landén NX, Pivarcsi A, Sonkoly E. Next generation sequencing identifies the keratinocyte-specific miRNA signature of psoriasis. J Invest Dermatol. 2019 Jun 14. pii: S0022-202X(19)31759-2. doi: 10.1016/j.jid.2019.05.019. [Epub ahead of print] PubMed PMID: 31207228.

18. Li D, Kular L, Vij M, Herter EK, Li X, Wang A, Chu T, Toma MA, Zhang L, Liapi E, Mota A, Blomqvist L, Gallais Sérézal I, Rollman O, Wikstrom JD, Bienko M, Berglund D, Ståhle M, Sommar P, Jagodic M, Landén NX. Human skin long noncoding RNA WAKMAR1 regulates wound healing by enhancing keratinocyte migration. Proc Natl Acad Sci U S A. 2019 May 7;116(19):9443-9452. doi: 10.1073/pnas.1814097116. Epub 2019 Apr 24. PubMed PMID: 31019085; PubMed Central PMCID: PMC6511036.

17. Pasquali, L. Srivastava, A. Meisgen, F. Das Mahapatra, K. Xia, P. Xu Landén, N. Pivarcsi, A. Sonkoly, E.The Keratinocyte Transcriptome in Psoriasis: Pathways Related to Immune Responses, Cell Cycle and Keratinization. Acta Derm Venereol, 2019. 99(2): p. 196-205. PMID: 30320872.

-------------------- 2018 --------------------

16. Herter EK, Li D, Toma MA, Vij M, Li X, Visscher D, Wang A, Chu T, Sommar P, Blomqvist L, Berglund D, Ståhle M, Wikstrom JD, Xu Landén N#. WAKMAR2, A Long Noncoding RNA Downregulated in Human Chronic Wounds, Modulates Keratinocyte Motility and Production of Inflammatory Chemokines, J Invest Dermatol. 2018 Dec 27. pii: S0022-202X(18)01301-5. doi: 10.1016/j.jid.2018.11.033. (#corresponding author)


15. Lohcharoenkal, W. Das Mahapatra, K. Pasquali, L. Crudden, C. Kular, L. Akkaya Ulum, Y. Z. Zhang, L. Xu Landén, N. Girnita, L. Jagodic, M. Stahle, M. Sonkoly, E. Pivarcsi, A.. Genome-Wide Screen for MicroRNAs Reveals a Role for miR-203 in Melanoma Metastasis. J Invest Dermatol, 2018. 138(4): p. 882-892. PMID: 29104160.

14. Gallais Sérézal lClasson CCheuk SBarrientos-Somarribas MWadman EMartini EChang DXu Landén NEhrström MNylén SEidsmo L. Resident T Cells in Resolved Psoriasis Steer Tissue Responses that Stratify Clinical OutcomeJ Invest Dermatol. 2018 Aug;138(8):1754-1763. PMID: 29510191.



-------------------- 2017 --------------------


13. Li X*, Li D*, Wang A, Chu T, Lohcharoenkal W, Zheng X, Grünler J, Narayanan S, Eliasson S, Herter E, Wang Y, Ma Y, Ehrström M, Eidsmo L, Pivarcsi A, Sonkoly E, Catrina S, Ståhle M, Xu Landén N#. MicroRNA-132 with therapeutic potential in chronic wounds. J Invest Dermatol. 2017 Aug 12. pii: S0022-202X(17)32757-4. doi: 10.1016/j.jid.2017.08.003. PMID: 28807666. (*Equal contribution, #corresponding author)


12. Li X, Li D, Wikström J.D., Pivarcsi A, Sonkoly E, Ståhle M, Xu Landén N# MicroRNA-132 promotes fibroblast migration via regulating RAS p21 protein activator 1 in skin wound healing. Sci Rep. 2017 Aug 10;7(1):7797. doi: 10.1038/s41598-017-07513-0. PMID: 28798331. (#corresponding author)


11. Li D, Landén NX#. MicroRNAs in skin wound healing. Eur J Dermatol. 2017 Jun 1;27(S1):12-14. doi: 10.1684/ejd.2017.3040. PMID: 28690209. (Review, #corresponding author)


10. Herter EK, Xu Landén N.# Non-Coding RNAs: New Players in Skin Wound Healing. Adv Wound Care (New Rochelle). 2017 Mar 1;6(3):93-107. PMID: 28289554 (Review, #corresponding author)


9. Wei, T., Folkersen, L., Biskup, E., Xu, N., Manfe, V., Niazi, O., Gniadecki, R. Ubiquitin-specific peptidase 2 as a potential link between microRNA-125b and psoriasis. British Journal of Dermatology 2017 Mar;176(3):723-731. PMID: 27479112


8. Srivastava, A., Nikamo, P., Lohcharoenkal, W., Li, D., Meisgen, F., Landén, N.X., Ståhle, M., Pivarcsi, A., Sonkoly, E. MicroRNA-146a suppresses IL-17-mediated skin inflammation and is genetically associated with psoriasis. J Allergy Clin Immunol 2017 Feb;139(2):550-561. PMID: 27568078.



-------------------- 2016 --------------------

7. Cheung, L., Fisher, R.M., Kuzmina, N., Li, D., Li, X., Werngren, O., Blomqvist, L., Ståhle, M., Landén, N.X.#.  (2016) Psoriasis skin inflammation-induced microRNA-26b targets NCEH1 in underlying subcutaneous adipose tissue. Journal of Investigative Dermatology 136: 640-648 PMID: 27015452 (#corresponding author)


6. Lohcharoenkal, W., Harada, M., Lovén, J., Meisgen, F., Landén, N.X., Zhang, L., Lapins, J., Mahapatra, K.D., Shi, H., Nissinen, L., Kähäri, V.M., Ståhle, M., Sonkoly, E., Grander, D., Arsenian-Henriksson, M., Pivarcsi, A. MicroRNA-203 inversely correlates with differentiation grade, targets c-MYC and functions as a tumor suppressor in cSCC. Journal of Investigative Dermatology 2016 Dec;136(12):2485-2494. PMID: 27452220.


5. Wei, Y.B., Melas,P.A., Villaescusa, J.C., Liu, J.J., Xu, N., Christiansen, S.H., Elbrønd-Bek, H., Woldbye, D.P., Wegener, G., Mathé, A.A., Lavebratt, C. MicroRNA 101b is downregulated in the prefrontal cortex of a genetic model of depression and targets the glutamate transporter SLC1A1 (EAAT3) in vitro. Int J Neuropsychopharmacol 2016 Dec 30;19(12). PMID:  27507301.


4: Landén NX#, Li D, Ståhle M. Transition from inflammation to proliferation: a critical step during wound healing. (2016) Cell Mol Life Sci. 73(20):3861-85. PMID: 27180275 (Review, #corresponding author)



-------------------- 2015 --------------------


3. Li, D.*, Wang, A.*, Liu, X., Meisgen, F., Grunler, J., Botusan, I.R., Narayanan, S., Erikci, E., Li, X., Blomqvist, L., Du, L., Pivarcsi, A., Sonkoly, E., Chowdhury, K., Catrina, S., Ståhle, M., Landén, N.X.#. (2015) MicroRNA-132 enhances transition from inflammation to proliferation during wound healing. Journal of Clinical Investigation 3;125(8):3008-26. PMID: 26121747 (*Equal contribution, #corresponding author)


2. Li, D., Wang, A., Meisgen, F., Pivarcsi, A., Sonkoly, E., Ståhle, M., Landén, N.X.#. (2015) MicroRNA-31 promotes skin wound healing by enhancing keratinocyte proliferation and migration. Journal of Investigative Dermatology 135(6): 1676-85 PMID: 25685928 (#corresponding author)


1. Wang, A., Landén, N.X. (2015) New insights into CD4+ T cells and their signature cytokines in atopic dermatitis. IUBMB Life 67(8): 601-10.  PMID: 26178387 (Review)



---------- Publications before Xu Landén Lab ----------


29. Checa, A., Xu, N., Sar, D.G., Haeggström, J.Z., Ståhle, M., Wheelock, C.E. (2015) Circulating levels of sphingosine-1-phosphate are elevated in severe, but not mild psoriasis and are unresponsive to anti-TNF-α treatment. Scientific Reports 2015 Jul 15; 5: 12017 PMID: 26174087


28. Li, J., Chen, H., Ren, J., Song, J., Zhang, F., Zhang, J., Lee, C., Li, S., Geng, Q., Cao, C., Xu, N. Effects of statin on circulating microRNAome and predicted function regulatory network in patients with unstable angina. BMC Med Genomics 8(1): 82 PMID: 25889164


27. Li, S., Chen, H., Ren, J., Geng, Q., Song, J., Lee, C., Cao, C., Zhang, J., Xu, N. (2014) MicroRNA-223 Inhibits Tissue Factor Expression in Vascular Endothelial Cells. Atherosclerosis 237(2): 514-20. PMID: 25463083


26. Kamleh, M., Snowden, S., Grapov, D., Blackburn, G., Watson, D., Xu, N., Ståhle, M., Wheelock, C. (2014) LC-MS metabolomics reveals systemic metabolic adaptations to protein requirement during keratinocyte hyperproliferation in psoriasis patients. Journal of Proteome Research 14(1): 557-66. PMID: 25361234


25. Wang, A#, Landén NX#, Lohcharoenkal, W., Ståhle, M., Sonkoly, E., Pivarcsi, A. (2014) MicroRNA-31 is overexpressed in cutaneous squamous cell carcinoma and regulates cell motility and colony formation ability of tumor cells. PLoS ONE Jul 28;9(7):e103206. PMID: 25068518 (#Co-first author)


24. Li, S., Ren, J., Xu, N., Zhang, J., Geng, Q., Cao, C., Lee, C., Song, J., Li, J., Chen, H. (2014) MicroRNA-19b functions as potential anti-thrombotic protector in patients with unstable angina by targeting tissue factor. Journal of Molecular and Cellular Cardiology Jul 3; 75C: 49-57 PMID: 24998411


23. Meisgen, F., Xu Landén, N., Wang, A., Réthi, B., Bovez, C., Zuccolo, M., Gueniche, A., Ståhle, M., Sonkoly, E., Breton, L., Pivarcsi, A. (2014). MiR-146a negatively regulates TLR2-induced inflammatory responses in keratinocytes.  Journal of Investigative Dermatology 134(7): 1931-40 PMID: 24670381


22. Hou, S, Ding H., Lv, Q, Yin, X., Song, J., Xu Landén, N., Fan, H., (2014) Therapeutic effect of intravenous infusion of perfluorocarbon emulsion on LPS-induced acute lung injury in rats. PLoS ONE Jan 28;9(1):e87826 PMID: 24489970


21. Meisgen, F.#, Xu Landén, N.#, Bouez, C., Zuccolo, M., Gueniche, A., Ståhle, M., Sonkoly, E., Breton, L., Pivarcsi, A. (2014) Activation of Toll-like receptors alters the microRNA expression profile of keratinocytes. Experimental Dermatology (*Co-first author) PMID: 24588688


20. Gastaldi, C., Bertero, T., Xu, N., Bourget-Ponzio, I., Popa, A., Cardot-Leccia, N., Michiels, J.F., Meneguzzi, G., Sonkoly, E., Pivarcsi, A., Mari, B., Barbry, P., Ponzio, G., Rezzonico, R. (2014) miR-193b/365a cluster controls progression of epidermal squamous cell carcinoma. Carcinogenesis 35(5):1110-20. PMID: 24374827


19. Nikamo, P., Cheuk, S., Lysell, J., Enerbäck, C., Bergh, K., Xu Landén, N., Eidsmo, L., Ståhle, M.  (2014) Genetic association of childhood psoriasis to the IL22 promoter is linked to higher promoter activity and increased IL-22 production in T cells. Journal of Investigative Dermatology 134(6):1535-41. PMID: 24390134


18. Wei, T.#, Xu, N.#, Meisgen, F., Ståhle, M., Sonkoly, E., Pivarcsi, A. (2013) Interleukin-8 is regulated by miR-203 at the posttranscriptional level in primary human keratinocytes. European Journal of Dermatology (* Co-first author) PMID: 23608026


17. Pivarcsi, A., Meisgen, F., Xu, N., Ståhle, M., Sonkoly, E. (2013) Changes in the level of serum microRNAs in psoriasispatients after anti-tumor necrosis factor-α therapy. British Journal of Dermatology 169(3): 563-70. PMID: 23600954


16. Ren, J., Zhang, J., Xu, N., Han G., Geng, Q., Song, J., Li, S., Zhao, J., Chen, H. (2013) Signature of Circulating MicroRNAs as Potential Biomarkers in Vulnerable Coronary Artery Disease. PLoS ONE 8(12):e80738  PMID: 24339880


15. Xu, N.#, Meisgen, F., Lynn, M.B., Han, G., Wang, X.J., Söderberg-Naucler, C., Ståhle, M., Pivarcsi, A., Sonkoly, E. (2012) MicroRNA-31 is overexpressed in psoriasis and modulates inflammatory cytokine and chemokine production in keratinocytes via targeting STK40. Journal of Immunology. 190(2): 678-88 (# Corresponding author) PMID: 23233723


14. Sääf, A., Kockum, I., Wahlgren, C.F., Xu, N., Sonkoly, E., Ståhle, M., Nordenskjöld, M., Bradley, M., Pivarcsi, A. (2012) Are BIC (miR-155) Polymorphisms Associated to Eczema Susceptibility? Acta Dermato-Venereologica. 93(3):366-7. PMID: 23047434


13. Xu, N#, Zhang L, Meisgen F, Harada M, Heilborn J, Homey B, Grander D, Ståhle M, Sonkoly E, Pivarcsi A. (2012) MicroRNA-125b Down-regulates Matrix Metallopeptidase 13 and Inhibits Cutaneous Squamous Cell Carcinoma Cell Proliferation, Migration and Invasion. Journal of Biological Chemistry. 287(35): 29899-908 (# Corresponding author) PMID: 22782903


12. Meisgen, F., Xu, N., Wei, T., Janson, P.C., Obad, S., Broom, O., Kauppinen, S. Nagy, N., Kemeny, L., Ståhle, M., Pivarcsi, A., Sonkoly, E. (2012) MiR-21 is up-regulated in psoriasis and suppresses T cell apoptosis. Experimental Dermatology. 21(4):312-4. PMID: 22417311


11. Sonkoly, E., Lovén, J., Xu, N., Meisgen, F., Wei, T., Brodin, P., Jaks, V., Kasper, M., Shimokawa, T., Harada, M., Heilborn, J., Hedblad, M.A., Hippe, A., Grandér, D., Homey, B., Zaphiropoulos, P.G., Arsenian-Henriksson, M., Ståhle, M., Pivarcsi, A. (2012) MicroRNA-203 Functions as a Tumor Suppressor in Basal Cell Carcinoma. Oncogenesis. Mar 12;1:e3. PMID: 23552555


10. Tang, H.M., Chen, H., Zhang, J. Ren, J.Y., Xu, N. (2012) Application of next generation sequencing in microRNA detection. HEREDITAS (Beijing) 34(6): 784-792.


9. Ren, J., Xu, N., Han, G., Chen, H., (2011). MicroRNAs in the Pathogenesis of Atherosclerosis. Chinese Journal of Biochemistry and Molecular Biology. V27 (6): 511-515


8. Xu, N.#, Brodin, P., Wei, T., Meisgen, F., Eidsmo, L., Nagy,N., Kemeny, L., Ståhle, M., Sonkoly, E., Pivarcsi, A. (2011) MiR-125b, a microRNA down-regulated in psoriasis, modulates keratinocyte proliferation by targeting FGFR2. Journal of Investigative Dermatology 131(7): 1521-9 (#Corresponding author) PMID: 21412257


7. Xu, N., Akusjärvi, G. (2011). Characterization of RISC associated adenoviral small RNAs. Methods in Molecular Medicine. 721:183-98. PMID: 21431686


6. Sonkoly, E., Janson, P., Majuri, M., Savinko, T., Fyhrquist, N., Eidsmo, L., Xu, N., Meisgen, F., Wei, T., Bradley, M., Stenvang, J., Kauppinen, S., Alenius, H., Lauerma, A., Homey, B., Winqvist, O., Ståhle, M., Pivarcsi, A. (2010) MiR-155 is overexpressed in atopic dermatitis and modulates T cell proliferative responses by targeting CTLA-4. Journal of Allergy and Clinical Immunology 126(3): 581-9.e1-20. PMID: 20673989


5. Wei, T., Orfanidis, K., Xu, N., Ståhle, M., Pivarcsi, A. and Sonkoly, E. (2010) The expression of microRNA-203 during human skin morphogenesis. Experimental Dermatology 19(9): 854-6. PMID: 20698882


4. Xu, N., Gkountela S., Khalid S., Akusjarvi G. (2009) The 5’ ends heterogeneity of adenovirus virus-associated RNAI contributes to the asymmetric guide strand incorporation into the RNA-induced silencing complex. Nucleic Acids Research. 37(20): 6950-9 PMID: 19755500


3. Xu, N., Segerman B., Zhou X., Akusjärvi, G. (2007) Adenovirus virus-associated RNAII-derived small RNAs are efficiently incorporated into the RNA-induced silencing complex and associate with polyribosomes. Journal of virology. 81, 10540-9 PMID: 17652395


2. Andersson, G., Xu, N. and Akusjärvi, G. (2007). In vitro methods to study RNA interference during an adenovirus infection. Methods in Molecular Medicine. 131, 47-61 PMID: 17656774


1. Andersson, M. G., Haasnoot, P. C. J., Xu, N., Berenjian, S., Berkhout, B. and Akusjärvi, G. (2005) Suppression of RNA interference by adenovirus VA RNA. Journal of virology. 79, 9556-9565. PMID: 16014917